maryam shkoohirad
Abstract
Abstract
The aim of this study was to investigate the effectiveness of biomedical treatments on the symptoms and satisfaction of families with autism spectrum disorder. The present research method was a semi-experimental pre-test-post-test type with a control group. The statistical population of this ...
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Abstract
The aim of this study was to investigate the effectiveness of biomedical treatments on the symptoms and satisfaction of families with autism spectrum disorder. The present research method was a semi-experimental pre-test-post-test type with a control group. The statistical population of this research was the autistic children of the autism group in virtual space, from which thirty autistic children aged four to twelve with autism, fifteen in the experimental group and fifteen in the control group were randomly assigned. The Autism Treatment Evaluation Checklist (ATEC) was used to collect research data. The program was conducted in three months by parents and the supervision of the researcher, and the research data was analyzed using the covariance analysis method. The results of covariance analysis showed that biomedical treatments in reducing the symptoms in the Autism Treatment Evaluation Checklist (ATEC) have caused families to be satisfied. It seems that with the continuation of this method and reaching higher stages of treatment, more changes can be made in reducing the symptoms of autism and following it, reducing the challenges of the families, leading to the families' satisfaction with the treatment.
Keywords: Biomedical Treatments, Family Satisfaction, Autism Spectrum Disorder.
Extended Abstract
Introduction
Autism is a complex neurodevelopmental genetics that is caused by a combination of environmental factors. In all areas of the child's development, it is affected and behaviorally, it is limited by social damage, indirect social connection and definition (Chast and Leboer, 2022). The personal and financial cost of an autistic person in families is very high (Hoffer et al., 2022). So far, only behavioral therapies have been the mainstay of managing this disorder (Pitson et al., 2020). The absence of effective treatments for the neurodevelopmental disorder of autism is significant (Aishwarya et al., 2022). The fact that autism treatment is unproven is itself a source of family dissatisfaction and requires an urgent need to focus on the mental health of the family and create consistency in the care of the autistic individual (Lerner, White and McPartland, 2022). Psychiatrically, there are still no approved medications for the main symptoms of the disorder, such as social and communication problems, repetitive behaviors, and secondary symptoms, such as irritability and aggression (Nirenius et al., 2022). Parents reported that supplements and diet were the most helpful treatments in reducing symptoms compared to other treatments they had used to treat autism (Adams et al., 2018). Since environmental chemicals and toxins are also associated with an increased risk of neurodevelopmental disorders and certain conditions such as autism. Research examines diet between environmental exposures and neurodevelopmental outcomes (Granro, 2022). Therefore, this research intends to determine the effectiveness of diet and supplements due to the types of severity of autism spectrum disorders and the lack of evidence of effectiveness (that drug treatments, behavioral therapies, and rehabilitation therapies have not led to treatment except for control and slight improvement). Natural biomedicals, with the help of their families, take a step towards knowing the solutions to reduce and improve the symptoms of autism. Therefore, due to the increase in the prevalence of autism all over the world in recent years, the need for various researches and more and more investigations in the field of discovering treatments that will guide us to the causes of autism is necessary.
Research Questions
Does diet affect neurodevelopmental outcomes? Is it possible to see a change in the symptoms of autism with diet and natural remedies and biomedicals?
Literature Review
Regarding biomedical treatments: in the meantime, biomedical treatments are related to the activation of the immune system and anti-inflammatory effects (Ostadkarmpour and Patnins, 2021). In a research, it was shown that there is a positive correlation between modulating glutamate in the basal ganglia and the balance of the excitatory-inhibitory system, with the reduction of autism symptoms (Pertzesh et al., 2019). Research has shown that early detection of the ratios of several mitochondrial biomarkers can predict autism and distinguish between high and low-functioning spectrums (Al-Ansari and others, 2018). In a research, it was shown that insufficient levels of vitamin D play a role in the severity of autism symptoms (Al-Ansari and others, 2018). Research has shown that digestive problems are highly associated with behavioral symptoms of autism (Magoid et al., 2022). In recent studies, the role of neuroinflammation in autism behaviors has been confirmed (Cristiano et al., 2022).
Methodology
This research was practical in terms of purpose and in terms of sampling method, it was a semi-experimental pre-test-post-test type with a control group. The statistical population of this research was made up of children with autism disorder aged 4 to 12 from the virtual autism group in Tehran. The inclusion criteria were having a diagnosis of autism from a psychiatrist and age 4 to 12 years. To obtain the required sample of participants with autism disorder in the virtual space group, 15 people were randomly selected. And 15 people were selected as the control group. Both groups first responded to the autism treatment evaluation checklist, and the evaluation score of their autism level in the pre-test was determined. The experimental group, with the full cooperation of their families, was subjected to a diet of complete elimination of sugar and sweets along with the use of biomedical methods for three months. The control group did not receive any intervention during this period. At the end of the three-month intervention period, the subjects of both groups responded to the autism treatment evaluation checklist, and their autism level evaluation score was determined in the post-test.
Results
In order to analyze the data, SPSS25 software and multivariate analysis of covariance were used. The presuppositions of using multivariate covariance analysis and homogeneity of variances were checked in Levine's test. The findings showed that the scores of the subjects of the experimental group in the post-test phase in the components of speech and communication, sociability, sensory-cognitive and physical health showed a decrease, but not much change was observed in the control group.
Table of the results of covariance analysis (MANCOVA) to investigate the significant difference between the two experimental and control groups in the components of speech and communication, sociability, sensory perception and physical health.
The dependent variable
sum of squares
DF
mean square
F
Sig
Ita
speech and communication
0.860
1
0.860
0.409
0.528
0.17
Sociability
0.009
1
0.009
0.005
0.944
0.001
sensory
0.197
1
0.197
0.414
0.526
0.017
physical health
0.991
1
0.991
0.210
0.651
0.009
speech and communication
91.980
1
91.980
43.803
0.001
0.65
Sociability
77.987
1
77.987
45.094
0.001
0.65
sensory
72.398
1
72.398
151.882
0.001
0.86
physical health
367.249
1
367.249
77.646
0.001
0.76
The results of the covariance analysis in the table show that after controlling for the pre-test effects, there is a statistically significant difference between the average scores of the two experimental and control groups in the total score of speech and communication (F=43.803). There were sociability (F=45.094), sensory (F=151.882), and physical health variables (F=77.646). According to the calculated effect size, 0.65, 0.65, 0.86 and 0.76 percent of the total variances of the experimental and control groups are due to the effect of the independent variable.